Product Name :
LMPTP INHIBITOR 1 hydrochloride
Description:
LMPTP INHIBITOR 1 (hydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
CAS:
2310135-38-5
Molecular Weight:
481.07
Formula:
C28H37ClN4O
Chemical Name:
N,N-diethyl-4-(4-[3-(piperidin-1-yl)propyl]aminoquinolin-2-yl)benzamide hydrochloride
Smiles :
Cl.CCN(CC)C(=O)C1C=CC(=CC=1)C1C=C(NCCCN2CCCCC2)C2=CC=CC=C2N=1
InChiKey:
WYRLEOWACOXSQP-UHFFFAOYSA-N
InChi :
InChI=1S/C28H36N4O.ClH/c1-3-32(4-2)28(33)23-15-13-22(14-16-23)26-21-27(24-11-6-7-12-25(24)30-26)29-17-10-20-31-18-8-5-9-19-31;/h6-7,11-16,21H,3-5,8-10,17-20H2,1-2H3,(H,29,30);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LMPTP INHIBITOR 1 (hydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.|Product information|CAS Number: 2310135-38-5|Molecular Weight: 481.07|Formula: C28H37ClN4O|Chemical Name: N,N-diethyl-4-(4-[3-(piperidin-1-yl)propyl]aminoquinolin-2-yl)benzamide hydrochloride|Smiles: Cl.CCN(CC)C(=O)C1C=CC(=CC=1)C1C=C(NCCCN2CCCCC2)C2=CC=CC=C2N=1|InChiKey: WYRLEOWACOXSQP-UHFFFAOYSA-N|InChi: InChI=1S/C28H36N4O.ClH/c1-3-32(4-2)28(33)23-15-13-22(14-16-23)26-21-27(24-11-6-7-12-25(24)30-26)29-17-10-20-31-18-8-5-9-19-31;/h6-7,11-16,21H,3-5,8-10,17-20H2,1-2H3,(H,29,30);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Xanomeline manufacturer |Shelf Life: ≥12 months if stored properly.Abagovomab supplier |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33250472 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|LMPTP INHIBITOR 1 (hydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50 of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes.|In Vivo:|LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight.|Products are for research use only. Not for human use.|
