Product Name :
Tivozanib
Description:
Tivozanib, also known as KRN951, is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.
CAS:
475108-18-0
Molecular Weight:
454.86
Formula:
C22H19ClN4O5
Chemical Name:
1-2-chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl-3-(5-methyl-1,2-oxazol-3-yl)urea
Smiles :
CC1=CC(NC(=O)NC2=CC=C(C=C2Cl)OC2=CC=NC3=CC(OC)=C(C=C32)OC)=NO1
InChiKey:
SPMVMDHWKHCIDT-UHFFFAOYSA-N
InChi :
InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Tivozanib, also known as KRN951, is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.Certolizumab pegol medchemexpress |Product information|CAS Number: 475108-18-0|Molecular Weight: 454.PCI-34051 HDAC 86|Formula: C22H19ClN4O5|Chemical Name: 1-2-chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl-3-(5-methyl-1,2-oxazol-3-yl)urea|Smiles: CC1=CC(NC(=O)NC2=CC=C(C=C2Cl)OC2=CC=NC3=CC(OC)=C(C=C32)OC)=NO1|InChiKey: SPMVMDHWKHCIDT-UHFFFAOYSA-N|InChi: InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32332483 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
