Product Name :
ZK824859
Description:
ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
CAS:
2271122-53-1
Molecular Weight:
428.43
Formula:
C23H22F2N2O4
Chemical Name:
(2R)-2-[(6-[3′-(aminomethyl)-5-methyl-[1,1′-biphenyl]-3-yl]oxy-3,5-difluoropyridin-2-yl)oxy]butanoic acid
Smiles :
CC1C=C(C=C(C=1)OC1N=C(O[C@H](CC)C(O)=O)C(F)=CC=1F)C1C=C(CN)C=CC=1
InChiKey:
CVNXUNVHFJANHX-HXUWFJFHSA-N
InChi :
InChI=1S/C23H22F2N2O4/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26/h4-11,20H,3,12,26H2,1-2H3,(H,28,29)/t20-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Minocycline Anti-infection
Shelf Life:
≥12 months if stored properly.Alectinib Protocol
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.PMID:33148076 |Product information|CAS Number: 2271122-53-1|Molecular Weight: 428.43|Formula: C23H22F2N2O4|Chemical Name: (2R)-2-[(6-[3′-(aminomethyl)-5-methyl-[1,1′-biphenyl]-3-yl]oxy-3,5-difluoropyridin-2-yl)oxy]butanoic acid|Smiles: CC1C=C(C=C(C=1)OC1N=C(O[C@H](CC)C(O)=O)C(F)=CC=1F)C1C=C(CN)C=CC=1|InChiKey: CVNXUNVHFJANHX-HXUWFJFHSA-N|InChi: InChI=1S/C23H22F2N2O4/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26/h4-11,20H,3,12,26H2,1-2H3,(H,28,29)/t20-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ZK824859 is 5 fold less potent and has lost selectivity in mouse: uPA IC50=410 nM; tPA IC50=910 nM; plasmin IC50=1600 nM compared to human IC50 values of 79 nM, 1580 nM and 1330 nM respectively.|In Vivo:|ZK824859 (50, 25 and 10 mg/kg; b.i.d.; 25 days) is used in a chronic mouse EAE model. ZK 824859 completely prevents the development of disease. However, two lower doses (25 and 10 mg/kg) have no effect on clinical scores.|Products are for research use only. Not for human use.|
