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Product Name :
SNT-207858

Description:
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.

CAS:
1104080-42-3

Molecular Weight:
689.54

Formula:
C32H45Cl4N5O3

Chemical Name:
N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-(4-3-[(2R)-2-(pyrrolidin-1-yl)butoxy]pyridin-2-ylpiperidin-1-yl)propan-2-yl]pyrrolidine-1-carboxamide dihydrochloride

Smiles :
Cl.Cl.CC[C@H](COC1=CC=CN=C1C1CCN(CC1)C(=O)[C@@H](CC1=CC=C(Cl)C=C1Cl)NC(=O)N1CCCC1)N1CCCC1

InChiKey:
DFRHMBGAOYBWHK-VXGCXGCYSA-N

InChi :
InChI=1S/C32H43Cl2N5O3.2ClH/c1-2-26(37-14-3-4-15-37)22-42-29-8-7-13-35-30(29)23-11-18-38(19-12-23)31(40)28(36-32(41)39-16-5-6-17-39)20-24-9-10-25(33)21-27(24)34;;/h7-10,13,21,23,26,28H,2-6,11-12,14-20,22H2,1H3,(H,36,41);2*1H/t26-,28-;;/m1../s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Indole-3-carbinol Formula

Additional information:
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.|Product information|CAS Number: 1104080-42-3|Molecular Weight: 689.54|Formula: C32H45Cl4N5O3|Chemical Name: N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-(4-3-[(2R)-2-(pyrrolidin-1-yl)butoxy]pyridin-2-ylpiperidin-1-yl)propan-2-yl]pyrrolidine-1-carboxamide dihydrochloride|Smiles: Cl.Abacavir MedChemExpress Cl.PMID:33280590 CC[C@H](COC1=CC=CN=C1C1CCN(CC1)C(=O)[C@@H](CC1=CC=C(Cl)C=C1Cl)NC(=O)N1CCCC1)N1CCCC1|InChiKey: DFRHMBGAOYBWHK-VXGCXGCYSA-N|InChi: InChI=1S/C32H43Cl2N5O3.2ClH/c1-2-26(37-14-3-4-15-37)22-42-29-8-7-13-35-30(29)23-11-18-38(19-12-23)31(40)28(36-32(41)39-16-5-6-17-39)20-24-9-10-25(33)21-27(24)34;;/h7-10,13,21,23,26,28H,2-6,11-12,14-20,22H2,1H3,(H,36,41);2*1H/t26-,28-;;/m1../s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5.|In Vivo:|SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice.|Products are for research use only. Not for human use.|

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Author: Sodium channel