Product Name :
iMDK quarterhydrate
Description:
iMDK quarterhydrate, a MDK-positive H441 and H520 lung adenocarcinoma cells inhibitor, suppresses the growth of H441 cells by inhibiting the PI3 kinase (PI3K) pathway and inducing apoptosis. iMDK quarterhydrate decreases MDK-induced migration, angiogenesis of endothelial cells and abrogats the progression and metastasis of NSCLC cells.
CAS:
Molecular Weight:
1523.63
Formula:
C84H54F4N8O9S4
Chemical Name:
3-[2-[(4-fluorophenyl)methyl]imidazo[2, 1-b][1, 3]thiazol-6-yl]chromen-2-one quarterhydrate
Smiles :
O.O=C1OC2=CC=CC=C2C=C1C1=CN2C=C(CC3C=CC(F)=CC=3)SC2=N1.O=C1OC2=CC=CC=C2C=C1C1=CN2C=C(CC3C=CC(F)=CC=3)SC2=N1.O=C1OC2=CC=CC=C2C=C1C1=CN2C=C(CC3C=CC(F)=CC=3)SC2=N1.O=C1OC2=CC=CC=C2C=C1C1=CN2C=C(CC3C=CC(F)=CC=3)SC2=N1
InChiKey:
TUJQZXTXYSRGBF-UHFFFAOYSA-N
InChi :
InChI=1S/4C21H13FN2O2S.H2O/c4*22-15-7-5-13(6-8-15)9-16-11-24-12-18(23-21(24)27-16)17-10-14-3-1-2-4-19(14)26-20(17)25;/h4*1-8,10-12H,9H2;1H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
iMDK quarterhydrate, a MDK-positive H441 and H520 lung adenocarcinoma cells inhibitor, suppresses the growth of H441 cells by inhibiting the PI3 kinase (PI3K) pathway and inducing apoptosis. iMDK quarterhydrate decreases MDK-induced migration, angiogenesis of endothelial cells and abrogats the progression and metastasis of NSCLC cells.|Product information|Molecular Weight: 1523.63|Formula: C84H54F4N8O9S4|Chemical Name: 3-[2-[(4-fluorophenyl)methyl]imidazo[2, 1-b][1, 3]thiazol-6-yl]chromen-2-one quarterhydrate|Smiles: O.O=C1OC2=CC=CC=C2C=C1C1=CN2C=C(CC3C=CC(F)=CC=3)SC2=N1.O=C1OC2=CC=CC=C2C=C1C1=CN2C=C(CC3C=CC(F)=CC=3)SC2=N1.O=C1OC2=CC=CC=C2C=C1C1=CN2C=C(CC3C=CC(F)=CC=3)SC2=N1.O=C1OC2=CC=CC=C2C=C1C1=CN2C=C(CC3C=CC(F)=CC=3)SC2=N1|InChiKey: TUJQZXTXYSRGBF-UHFFFAOYSA-N|InChi: InChI=1S/4C21H13FN2O2S.Phosphatidylserine In Vitro H2O/c4*22-15-7-5-13(6-8-15)9-16-11-24-12-18(23-21(24)27-16)17-10-14-3-1-2-4-19(14)26-20(17)25;/h4*1-8,10-12H,9H2;1H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.CF53 In Vitro |Shelf Life: ≥12 months if stored properly.PMID:33213294 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|iMDK inhibits endogenous MDK expression in H441 lung adenocarcinoma cells, induces apoptosis in H441 lung adenocarcinoma cells.|In Vivo:|iMDK (9mg/kg; 1 time/2 days) exhibits anti-tumor and anti-metastasis effects on a xenograft mouse model of NSCLC.|Products are for research use only. Not for human use.|
