Product Name :
RIG-I (human) polyclonal antibody (AT111)
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Stable for at least 1 year after receipt when stored at -20°C.
Description:
RIG-I (retinoic acid-inducible gene I; Ddx58), a member of the DEAD-box RNA helicases, is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-β (Cardif) in a CARD-CARD-dependent manner resulting in NF-κB and IRF3 activation.
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Additional Information :
| Alternative Name RIG-1, Retinoic acid-inducible gene 1 protein, DEAD-box protein 58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 M, Probable ATP-dependent RNA helicase DDX58 | Application IP, WB | Formulation Liquid.1450833-55-2 medchemexpress In PBS containing 0.243984-11-4 Biological Activity 02% sodium azide.PMID:20301580 | Host Rabbit | Immunogen Recombinant human RIG-I (aa 201-713). | Recommendation Dilutions/Conditions Immunoprecipitation (1:100)Western blot (1:1,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from rabbit serum. | Species Reactivity Human | UniProt ID O95786 | Unit of Measure (UM) µg
