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[pSer315]p53 monoclonal antibody (FPS315)
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p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to Mdm2, SV40 T antigen and human Papilloma virus E6 protein. p53 senses DNA damage and facilitates its repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovary, bladder, colon, lung, and melanoma.
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| Alternative Name TRP53, Tumor protein p53 | Application WB | Application Notes Western Blot (5µg/ml, ECL)Optimal conditions must be determined individually for each application.{{118063-12-0} site|{118063-12-0} Biological Activity|{118063-12-0} In Vivo|{118063-12-0} supplier} | Clone FPS315 | Formulation Liquid.{{1453084-37-1} medchemexpress|{1453084-37-1} Purity & Documentation|{1453084-37-1} References|{1453084-37-1} supplier} In PBS, pH 7.PMID:30000194 2, containing 50% glycerol. | Host Mouse | Immunogen Synthetic peptide corresponding to a portion of human p53 phosphorylated at Ser315. | Isotype IgG1 | Recommendation Dilutions/Conditions Western Blot (5µg/ml, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Species Reactivity Human | UniProt ID P04637 | Unit of Measure (UM) µg
