Product Name :
KDM5A-IN-1
Description:
KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B).
CAS:
1905481-36-8
Molecular Weight:
290.36
Formula:
C15H22N4O2
Chemical Name:
N-[(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl]cyclopropanecarboxamide
Smiles :
CC(C)C1C=C(NN=1)C(=O)N1CC[C@H](C1)NC(=O)C1CC1
InChiKey:
CXEXTVGTDZRKJS-LLVKDONJSA-N
InChi :
InChI=1S/C15H22N4O2/c1-9(2)12-7-13(18-17-12)15(21)19-6-5-11(8-19)16-14(20)10-3-4-10/h7,9-11H,3-6,8H2,1-2H3,(H,16,20)(H,17,18)/t11-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3.{{Ranibizumab (anti-VEGF)} MedChemExpress|{Ranibizumab (anti-VEGF)} VEGFR|{Ranibizumab (anti-VEGF)} Biological Activity|{Ranibizumab (anti-VEGF)} References|{Ranibizumab (anti-VEGF)} supplier|{Ranibizumab (anti-VEGF)} Autophagy} KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B).{{Neratinib} MedChemExpress|{Neratinib} EGFR|{Neratinib} Technical Information|{Neratinib} Purity|{Neratinib} custom synthesis|{Neratinib} Epigenetics} |Product information|CAS Number: 1905481-36-8|Molecular Weight: 290.PMID:23453497 36|Formula: C15H22N4O2|Chemical Name: N-[(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl]cyclopropanecarboxamide|Smiles: CC(C)C1C=C(NN=1)C(=O)N1CC[C@H](C1)NC(=O)C1CC1|InChiKey: CXEXTVGTDZRKJS-LLVKDONJSA-N|InChi: InChI=1S/C15H22N4O2/c1-9(2)12-7-13(18-17-12)15(21)19-6-5-11(8-19)16-14(20)10-3-4-10/h7,9-11H,3-6,8H2,1-2H3,(H,16,20)(H,17,18)/t11-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 50 mg/mL (172.20 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|KDM5A-IN-1 (Compound 50, 5 mg/kg; oral administration; female CD-1 mice) treatment shows moderate clearance (28 mL/min/kg) in mice with good oral bioavailability (F% 34) and remarkably low plasma protein binding in mice (40%), with t1/2 of 0.4 hours.|Products are for research use only. Not for human use.|
