Product Name :
LY2955303
Description:
LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.
CAS:
1433497-19-8
Molecular Weight:
578.74
Formula:
C36H42N4O3
Chemical Name:
4-[5-(3,5-di-tert-butylphenyl)-1-[4-(4-methylpiperazine-1-carbonyl)phenyl]-1H-pyrazol-3-yl]benzoic acid
Smiles :
CN1CCN(CC1)C(=O)C1C=CC(=CC=1)N1N=C(C=C1C1C=C(C=C(C=1)C(C)(C)C)C(C)(C)C)C1C=CC(=CC=1)C(O)=O
InChiKey:
YVXYHNKIOFSFMZ-UHFFFAOYSA-N
InChi :
InChI=1S/C36H42N4O3/c1-35(2,3)28-20-27(21-29(22-28)36(4,5)6)32-23-31(24-8-10-26(11-9-24)34(42)43)37-40(32)30-14-12-25(13-15-30)33(41)39-18-16-38(7)17-19-39/h8-15,20-23H,16-19H2,1-7H3,(H,42,43)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Estrone} web|{Estrone} Vitamin D Related/Nuclear Receptor|{Estrone} Protocol|{Estrone} Purity|{Estrone} custom synthesis|{Estrone} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.|Product information|CAS Number: 1433497-19-8|Molecular Weight: 578.74|Formula: C36H42N4O3|Chemical Name: 4-[5-(3,5-di-tert-butylphenyl)-1-[4-(4-methylpiperazine-1-carbonyl)phenyl]-1H-pyrazol-3-yl]benzoic acid|Smiles: CN1CCN(CC1)C(=O)C1C=CC(=CC=1)N1N=C(C=C1C1C=C(C=C(C=1)C(C)(C)C)C(C)(C)C)C1C=CC(=CC=1)C(O)=O|InChiKey: YVXYHNKIOFSFMZ-UHFFFAOYSA-N|InChi: InChI=1S/C36H42N4O3/c1-35(2,3)28-20-27(21-29(22-28)36(4,5)6)32-23-31(24-8-10-26(11-9-24)34(42)43)37-40(32)30-14-12-25(13-15-30)33(41)39-18-16-38(7)17-19-39/h8-15,20-23H,16-19H2,1-7H3,(H,42,43)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 30 mg/mL (51.{{MK-1084} web|{MK-1084} MAPK/ERK Pathway|{MK-1084} TGF-beta/Smad|{MK-1084} Biological Activity|{MK-1084} Purity|{MK-1084} custom synthesis} 84 mM; Need ultrasonic and warming).PMID:26644518 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|LY2955303 is tested and observed that the binding Kis for RARα, RARβ and RARγ are >1700, >2980 and 1.09 nM, respectively. The functional Ki for RARγ is 7.1±4.9 nM.|In Vivo:|A single oral dose of LY2955303 demonstrates a dose responsive effect whereby the rat reduces differential weight bearing (ED50=0.72 mg/kg).|Products are for research use only. Not for human use.|
