Product Name :
Folinic acid (calcium salt pentahydrate)
Description:
Leucovorin calcium is a n active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, ‘rescuing’ the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug’s metabolite to its target enzyme, thus prolonging drug activity.
CAS:
6035-45-6
Molecular Weight:
601.58
Formula:
C20H31CaN7O12
Chemical Name:
calcium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioate pentahydrate
Smiles :
O.O.O.O.O.[Ca+2].NC1NC(=O)C2=C(NCC(CNC3C=CC(=CC=3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)N2C=O)N=1
InChiKey:
NPPBLUASYYNAIG-ZIGBGYJWSA-L
InChi :
InChI=1S/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;5*1H2/q;+2;;;;;/p-2/t12?,13-;;;;;;/m0……/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Simvastatin} web|{Simvastatin} Metabolic Enzyme/Protease|{Simvastatin} Biological Activity|{Simvastatin} In Vivo|{Simvastatin} supplier|{Simvastatin} Autophagy}
Additional information:
Leucovorin calcium is a n active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs.{{Fluphenazine} medchemexpress|{Fluphenazine} GPCR/G Protein|{Fluphenazine} Technical Information|{Fluphenazine} Data Sheet|{Fluphenazine} manufacturer|{Fluphenazine} Epigenetic Reader Domain} Leucovorin calcium counteracts the toxic effects of these medications, ‘rescuing’ the patient while permitting the antitumor activity of the folate antagonist.PMID:35227773 This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug’s metabolite to its target enzyme, thus prolonging drug activity.|Product information|CAS Number: 6035-45-6|Molecular Weight: 601.58|Formula: C20H31CaN7O12|Chemical Name: calcium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioate pentahydrate|Smiles: O.O.O.O.O.[Ca+2].NC1NC(=O)C2=C(NCC(CNC3C=CC(=CC=3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)N2C=O)N=1|InChiKey: NPPBLUASYYNAIG-ZIGBGYJWSA-L|InChi: InChI=1S/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;5*1H2/q;+2;;;;;/p-2/t12?,13-;;;;;;/m0……/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
