Product Name :
WZ4003
Description:
WZ4003 is a selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. WZ4003 inhibits both NUAK isoforms (IC50 for NUAK1 is 20 nM and for NUAK2 is 100 nM). WZ4003 displays extreme selectivity and do not significantly inhibit the activity of 139 other kinases that were tested including ten AMPK family members. In all cell lines tested, WZ4003 inhibits the phosphorylation of the only well-characterized substrate, MYPT1 (myosin phosphate-targeting subunit 1) that is phosphorylated by NUAK1 at Ser(445).
CAS:
1214265-58-3
Molecular Weight:
496.99
Formula:
C25H29ClN6O3
Chemical Name:
N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}propanamide
Smiles :
CN1CCN(CC1)C1=CC(OC)=C(C=C1)NC1=NC(OC2=CC(=CC=C2)NC(=O)CC)=C(Cl)C=N1
InChiKey:
SDGJBAUIGHSMRI-UHFFFAOYSA-N
InChi :
InChI=1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
WZ4003 is a selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases.{{Merocyanin 540} site|{Merocyanin 540} {Fluorescent Dye}|{Merocyanin 540} Purity & Documentation|{Merocyanin 540} In Vitro|{Merocyanin 540} custom synthesis|{Merocyanin 540} Epigenetics} WZ4003 inhibits both NUAK isoforms (IC50 for NUAK1 is 20 nM and for NUAK2 is 100 nM).{{Oxiracetam} medchemexpress|{Oxiracetam} Neuronal Signaling|{Oxiracetam} Immunology/Inflammation|{Oxiracetam} Technical Information|{Oxiracetam} Description|{Oxiracetam} supplier} WZ4003 displays extreme selectivity and do not significantly inhibit the activity of 139 other kinases that were tested including ten AMPK family members.PMID:23671446 In all cell lines tested, WZ4003 inhibits the phosphorylation of the only well-characterized substrate, MYPT1 (myosin phosphate-targeting subunit 1) that is phosphorylated by NUAK1 at Ser(445).|Product information|CAS Number: 1214265-58-3|Molecular Weight: 496.99|Formula: C25H29ClN6O3|Chemical Name: N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}propanamide|Smiles: CN1CCN(CC1)C1=CC(OC)=C(C=C1)NC1=NC(OC2=CC(=CC=C2)NC(=O)CC)=C(Cl)C=N1|InChiKey: SDGJBAUIGHSMRI-UHFFFAOYSA-N|InChi: InChI=1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
