Product Name :
Fmoc-Ala-Glu-Asn-Lys-NH2
Description:
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing.
CAS:
220701-06-4
Molecular Weight:
681.74
Formula:
C33H43N7O9
Chemical Name:
(4S)-4-{[(1S)-1-{[(1S)-5-amino-1-carbamoylpentyl]carbamoyl}-2-carbamoylethyl]carbamoyl}-4-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]butanoic acid
Smiles :
C[C@H](NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O
InChiKey:
SAWVPDQXSCHRKB-UZTPZCRESA-N
InChi :
InChI=1S/C33H43N7O9/c1-18(37-33(48)49-17-23-21-10-4-2-8-19(21)20-9-3-5-11-22(20)23)30(45)39-25(13-14-28(42)43)31(46)40-26(16-27(35)41)32(47)38-24(29(36)44)12-6-7-15-34/h2-5,8-11,18,23-26H,6-7,12-17,34H2,1H3,(H2,35,41)(H2,36,44)(H,37,48)(H,38,47)(H,39,45)(H,40,46)(H,42,43)/t18-,24-,25-,26-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing.|Product information|CAS Number: 220701-06-4|Molecular Weight: 681.74|Formula: C33H43N7O9|Chemical Name: (4S)-4-{[(1S)-1-{[(1S)-5-amino-1-carbamoylpentyl]carbamoyl}-2-carbamoylethyl]carbamoyl}-4-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]butanoic acid|Smiles: C[C@H](NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O|InChiKey: SAWVPDQXSCHRKB-UZTPZCRESA-N|InChi: InChI=1S/C33H43N7O9/c1-18(37-33(48)49-17-23-21-10-4-2-8-19(21)20-9-3-5-11-22(20)23)30(45)39-25(13-14-28(42)43)31(46)40-26(16-27(35)41)32(47)38-24(29(36)44)12-6-7-15-34/h2-5,8-11,18,23-26H,6-7,12-17,34H2,1H3,(H2,35,41)(H2,36,44)(H,37,48)(H,38,47)(H,39,45)(H,40,46)(H,42,43)/t18-,24-,25-,26-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (146.{{Cinacalcet} web|{Cinacalcet} Endogenous Metabolite|{Cinacalcet} Technical Information|{Cinacalcet} Data Sheet|{Cinacalcet} manufacturer|{Cinacalcet} Epigenetic Reader Domain} 68 mM; ultrasonic and warming and heat to 80°C).{{Indacaterol} web|{Indacaterol} Neuronal Signaling|{Indacaterol} Technical Information|{Indacaterol} In Vitro|{Indacaterol} custom synthesis|{Indacaterol} Epigenetic Reader Domain} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24318587 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect.|Products are for research use only. Not for human use.|
