Product Name :
Tripamide
Description:
Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent.
CAS:
73803-48-2
Molecular Weight:
369.87
Formula:
C16H20ClN3O3S
Chemical Name:
N-[(1R,2S,6R,7S)-4-azatricyclo[5.2.1.0²,⁶]decan-4-yl]-4-chloro-3-sulfamoylbenzamide
Smiles :
NS(=O)(=O)C1=CC(=CC=C1Cl)C(=O)NN1C[C@H]2[C@H]3C[C@H](CC3)[C@H]2C1
InChiKey:
UHLOVGKIEARANS-QZHINBJYSA-N
InChi :
InChI=1S/C16H20ClN3O3S/c17-14-4-3-11(6-15(14)24(18,22)23)16(21)19-20-7-12-9-1-2-10(5-9)13(12)8-20/h3-4,6,9-10,12-13H,1-2,5,7-8H2,(H,19,21)(H2,18,22,23)/t9-,10+,12+,13-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent.|Product information|CAS Number: 73803-48-2|Molecular Weight: 369.87|Formula: C16H20ClN3O3S|Chemical Name: N-[(1R,2S,6R,7S)-4-azatricyclo[5.2.1.0²,⁶]decan-4-yl]-4-chloro-3-sulfamoylbenzamide|Smiles: NS(=O)(=O)C1=CC(=CC=C1Cl)C(=O)NN1C[C@H]2[C@H]3C[C@H](CC3)[C@H]2C1|InChiKey: UHLOVGKIEARANS-QZHINBJYSA-N|InChi: InChI=1S/C16H20ClN3O3S/c17-14-4-3-11(6-15(14)24(18,22)23)16(21)19-20-7-12-9-1-2-10(5-9)13(12)8-20/h3-4,6,9-10,12-13H,1-2,5,7-8H2,(H,19,21)(H2,18,22,23)/t9-,10+,12+,13-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Tripamide (less than 10 μg/ml) does not modify the membrane potential and resistance, but does suppress the spike evoked by outward current pulses in the presence of 3-5 mM TEA. In the mesenteric artery, Tripamide suppresses the amplitude of e.{{TSLP Protein, Human} medchemexpress|{TSLP Protein, Human} Purity & Documentation|{TSLP Protein, Human} In stock|{TSLP Protein, Human} custom synthesis|{TSLP Protein, Human} Cancer} j.{{Anti-Mouse CD209b Antibody} medchemexpress|{Anti-Mouse CD209b Antibody} Purity & Documentation|{Anti-Mouse CD209b Antibody} Formula|{Anti-Mouse CD209b Antibody} supplier|{Anti-Mouse CD209b Antibody} Autophagy} ps evoked by perivascular nerve stimulation.PMID:23962101 However, the facilitation process produced by repetitive stimulation is less affected by Tripamide.|In Vivo:|In rats loaded orally with 25 ml/kg of normal saline, Tripamide (0.6-160 mg/kg) increases urine volume and sodium and chloride excretion in a dose-dependent fashion. Only at a dose of 160 mg/kg, there an increase in potassiumexcretion in rats. Tripamide has anti-hypertensive effects, during administration to spontaneously hypertensive rats at a dose of 10 mg/kg/day for 4 weeks, tripamide doubled urine volume and sodium excretion, while potassium excretion is increased by Products are for research use only. Not for human use.|
