Product Name :
OAC1 — Oct4 Activator
Description:
OAC1 is a potent and selective small molecule to activate both Oct4 and Nanog promoter-driven luciferase reporter genes, identified from a cell-based high-throughput screening. When added to the reprogramming media along with the four reprogramming factors (Oct4, Sox2, Klf4, and c-Myc), OAC1 can significantly enhance iPSC reprogramming efficiency (20-fold higher than that induced by the 4F alone) and accelerate the reprogramming process. The iPSC colonies derived using OAC1 along with the four factors exhibited typical ESC morphology, gene-expression pattern, and developmental potential. OAC1 seems to enhance reprogramming efficiency in a unique manner, independent of either inhibition of the p53-p21 pathway or activation of the Wnt-β-catenin signaling. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. OAC1 may be used for large-scale iPSC generation for various applications.
CAS:
300586-90-7
Molecular Weight:
237.26
Formula:
C14H11N3O
Chemical Name:
N-(1H-pyrrolo[2,3-c]pyridin-5-yl)benzamide
Smiles :
O=C(NC1C=C2C=CNC2=CN=1)C1C=CC=CC=1
InChiKey:
HWJRIFZDXJKJJN-UHFFFAOYSA-N
InChi :
InChI=1S/C14H11N3O/c18-14(10-4-2-1-3-5-10)17-13-8-11-6-7-15-12(11)9-16-13/h1-9,15H,(H,16,17,18)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
OAC1 is a potent and selective small molecule to activate both Oct4 and Nanog promoter-driven luciferase reporter genes, identified from a cell-based high-throughput screening. When added to the reprogramming media along with the four reprogramming factors (Oct4, Sox2, Klf4, and c-Myc), OAC1 can significantly enhance iPSC reprogramming efficiency (20-fold higher than that induced by the 4F alone) and accelerate the reprogramming process. The iPSC colonies derived using OAC1 along with the four factors exhibited typical ESC morphology, gene-expression pattern, and developmental potential. OAC1 seems to enhance reprogramming efficiency in a unique manner, independent of either inhibition of the p53-p21 pathway or activation of the Wnt-β-catenin signaling.{{Domperidone} MedChemExpress|{Domperidone} GPCR/G Protein|{Domperidone} Technical Information|{Domperidone} References|{Domperidone} custom synthesis|{Domperidone} Autophagy} OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. OAC1 may be used for large-scale iPSC generation for various applications.|Product information|CAS Number: 300586-90-7|Molecular Weight: 237.26|Formula: C14H11N3O|Chemical Name: N-(1H-pyrrolo[2,3-c]pyridin-5-yl)benzamide|Smiles: O=C(NC1C=C2C=CNC2=CN=1)C1C=CC=CC=1|InChiKey: HWJRIFZDXJKJJN-UHFFFAOYSA-N|InChi: InChI=1S/C14H11N3O/c18-14(10-4-2-1-3-5-10)17-13-8-11-6-7-15-12(11)9-16-13/h1-9,15H,(H,16,17,18)|Technical Data|Appearance: Solid Power.{{Tusamitamab} site|{Tusamitamab} Others|{Tusamitamab} Epigenetics|{Tusamitamab} Purity & Documentation|{Tusamitamab} Purity|{Tusamitamab} custom synthesis} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:25429455 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|OAC1 was used at 1 µM final concentration in iPSC culture media for 7 days (2 days after viral transduction with the four reprogramming factors).|References:|Li W, et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. (2012) Proc Natl Acad Sci USA.109(51):20853-8.Products are for research use only. Not for human use.|Documents||
