Product Name :
AGI-6780 — Mutant IDH2 Inhibitor
Description:
AGI-6780 is a potent and selective IDH2 inhibitor. AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q. Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. Inhibitors targeting mutant IDH2/R140Q could have potential applications as a differentiation therapy for cancer.
CAS:
1432660-47-3
Molecular Weight:
481.51
Formula:
C21H18F3N3O3S2
Chemical Name:
N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide
Smiles :
O=C(NC1=CC=CC(=C1)C(F)(F)F)NC1=CC(=CC=C1C1=CSC=C1)S(=O)(=O)NC1CC1
InChiKey:
CCAWRGNYALGPQH-UHFFFAOYSA-N
InChi :
InChI=1S/C21H18F3N3O3S2/c22-21(23,24)14-2-1-3-16(10-14)25-20(28)26-19-11-17(32(29,30)27-15-4-5-15)6-7-18(19)13-8-9-31-12-13/h1-3,6-12,15,27H,4-5H2,(H2,25,26,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Icariin} site|{Icariin} Phosphodiesterase (PDE)|{Icariin} Protocol|{Icariin} In Vivo|{Icariin} supplier|{Icariin} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AGI-6780 is a potent and selective IDH2 inhibitor. AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q. Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. Inhibitors targeting mutant IDH2/R140Q could have potential applications as a differentiation therapy for cancer.|Product information|CAS Number: 1432660-47-3|Molecular Weight: 481.51|Formula: C21H18F3N3O3S2|Chemical Name: N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide|Smiles: O=C(NC1=CC=CC(=C1)C(F)(F)F)NC1=CC(=CC=C1C1=CSC=C1)S(=O)(=O)NC1CC1|InChiKey: CCAWRGNYALGPQH-UHFFFAOYSA-N|InChi: InChI=1S/C21H18F3N3O3S2/c22-21(23,24)14-2-1-3-16(10-14)25-20(28)26-19-11-17(32(29,30)27-15-4-5-15)6-7-18(19)13-8-9-31-12-13/h1-3,6-12,15,27H,4-5H2,(H2,25,26,28)|Technical Data|Appearance: Solid Power.{{Atorvastatin} site|{Atorvastatin} HMG-CoA Reductase (HMGCR)|{Atorvastatin} Technical Information|{Atorvastatin} Description|{Atorvastatin} custom synthesis|{Atorvastatin} Epigenetics} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 50 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23892746 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|AGI-6780 was suggested to be used at 1-5 µM final concentration in vitro.|References:|Fang Wang, et al. Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation. (2013) Science. 340(6132):622-6.Products are for research use only. Not for human use.|Documents||
