Product Name :
Irinotecan-d10(hydrochloride)
Description:
Irinotecan-d10 ((+)-Irinotecan-d10) hydrochloride is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.
CAS:
718612-62-5
Molecular Weight:
633.20
Formula:
C33H39ClN4O6
Chemical Name:
(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl (2,2,3,3,4,4,5,5,6,6-²H₁₀)-[1,4′-bipiperidine]-1′-carboxylate hydrochloride
Smiles :
Cl.[2H]C1([2H])C([2H])([2H])C([2H])([2H])N(C2CCN(CC2)C(=O)OC2C=CC3=NC4C5=CC6=C(COC(=O)[C@]6(O)CC)C(=O)N5CC=4C(CC)=C3C=2)C([2H])([2H])C1([2H])[2H]
InChiKey:
GURKHSYORGJETM-SLLIWMIESA-N
InChi :
InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1/i5D2,6D2,7D2,12D2,13D2;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Irinotecan-d10 ((+)-Irinotecan-d10) hydrochloride is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.|Product information|CAS Number: 718612-62-5|Molecular Weight: 633.20|Formula: C33H39ClN4O6|Chemical Name: (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.Custom Peptide Synthesis 8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl (2,2,3,3,4,4,5,5,6,6-²H₁₀)-[1,4′-bipiperidine]-1′-carboxylate hydrochloride|Smiles: Cl.[2H]C1([2H])C([2H])([2H])C([2H])([2H])N(C2CCN(CC2)C(=O)OC2C=CC3=NC4C5=CC6=C(COC(=O)[C@]6(O)CC)C(=O)N5CC=4C(CC)=C3C=2)C([2H])([2H])C1([2H])[2H]|InChiKey: GURKHSYORGJETM-SLLIWMIESA-N|InChi: InChI=1S/C33H38N4O6.{{Diosmin} site|{Diosmin} Immunology/Inflammation|{Diosmin} Technical Information|{Diosmin} References|{Diosmin} manufacturer|{Diosmin} Cancer} ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0.PMID:24013184 /s1/i5D2,6D2,7D2,12D2,13D2;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.|Products are for research use only. Not for human use.|
