Product Name :
Biotin-PEG4-Dde-TAMRA-PEG3-Azide
Description:
Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
CAS:
2353409-56-8
Molecular Weight:
1397.64
Formula:
C69H96N12O17S
Chemical Name:
5-{[2-({2-[(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}-15-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)-3,6,9,12-tetraoxa-16-azanonadec-15-en-19-yl)carbamoyl]ethyl}(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)carbamoyl)ethyl]carbamoyl}-2-[6-(dimethylamino)-3-imino-3H-xanthen-9-yl]benzoic acid
Smiles :
CN(C)C1=CC2OC3=CC(=N)C=CC3=C(C3=CC=C(C=C3C(O)=O)C(=O)NCCC(=O)N(CCOCCOCCOCCN=[N+]=[N-])CCC(=O)NCCCN=C(CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)C3C(=O)CC(C)(C)CC=3O)C=2C=C1
InChiKey:
BZMNWSIWUFJKEL-DACNLSJESA-N
InChi :
InChI=1S/C69H96N12O17S/c1-69(2)43-55(82)64(56(83)44-69)53(18-26-91-30-34-95-38-39-97-35-31-92-27-22-74-60(84)9-6-5-8-59-65-54(45-99-59)77-68(90)78-65)72-19-7-20-73-61(85)17-24-81(25-29-94-33-37-96-36-32-93-28-23-76-79-71)62(86)16-21-75-66(87)46-10-13-49(52(40-46)67(88)89)63-50-14-11-47(70)41-57(50)98-58-42-48(80(3)4)12-15-51(58)63/h10-15,40-42,54,59,65,70,82H,5-9,16-39,43-45H2,1-4H3,(H,73,85)(H,74,84)(H,75,87)(H,88,89)(H2,77,78,90)/b70-47?,72-53+/t54-,59-,65-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Lumasiran} web|{Lumasiran} Epigenetics|{Lumasiran} Purity & Documentation|{Lumasiran} In Vitro|{Lumasiran} custom synthesis|{Lumasiran} Cancer}
Shelf Life:
≥12 months if stored properly.{{Rituximab} MedChemExpress|{Rituximab} Immunology/Inflammation|{Rituximab} Biological Activity|{Rituximab} References|{Rituximab} manufacturer|{Rituximab} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24179643
Additional information:
Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).|Product information|CAS Number: 2353409-56-8|Molecular Weight: 1397.64|Formula: C69H96N12O17S|Chemical Name: 5-{[2-({2-[(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}-15-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)-3,6,9,12-tetraoxa-16-azanonadec-15-en-19-yl)carbamoyl]ethyl}(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)carbamoyl)ethyl]carbamoyl}-2-[6-(dimethylamino)-3-imino-3H-xanthen-9-yl]benzoic acid|Smiles: CN(C)C1=CC2OC3=CC(=N)C=CC3=C(C3=CC=C(C=C3C(O)=O)C(=O)NCCC(=O)N(CCOCCOCCOCCN=[N+]=[N-])CCC(=O)NCCCN=C(CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)C3C(=O)CC(C)(C)CC=3O)C=2C=C1|InChiKey: BZMNWSIWUFJKEL-DACNLSJESA-N|InChi: InChI=1S/C69H96N12O17S/c1-69(2)43-55(82)64(56(83)44-69)53(18-26-91-30-34-95-38-39-97-35-31-92-27-22-74-60(84)9-6-5-8-59-65-54(45-99-59)77-68(90)78-65)72-19-7-20-73-61(85)17-24-81(25-29-94-33-37-96-36-32-93-28-23-76-79-71)62(86)16-21-75-66(87)46-10-13-49(52(40-46)67(88)89)63-50-14-11-47(70)41-57(50)98-58-42-48(80(3)4)12-15-51(58)63/h10-15,40-42,54,59,65,70,82H,5-9,16-39,43-45H2,1-4H3,(H,73,85)(H,74,84)(H,75,87)(H,88,89)(H2,77,78,90)/b70-47?,72-53+/t54-,59-,65-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|Products are for research use only. Not for human use.|
