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Ritis Rheum 2010, 62:2776786. five. Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L: Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: part of indoleamine two,3dioxygenase and prostaglandin E2. Blood 2008, 111:1327333. six. Djouad F, Charbonnier LM, Bouffi C, Louis-Plence P, Bony C, Apparailly F, Cantos C, Jorgensen C, Noel D: Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanism. Stem Cells 2007, 25:2025032. 7. English K, Barry FP, Field-Corbett CP, Mahon BP: IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells. Immunol Lett 2007, 110:9100. 8. English K, Ryan JM, Tobin L, Murphy MJ, Barry FP, Mahon BP: Cell get in touch with, prostaglandin E(2) and transforming development element beta 1 play nonredundant roles in human mesenchymal stem cell induction of CD4 + CD25(Higher) forkhead box P3+ regulatory T cells.Apixaban Clin Exp Immunol 2009, 156:14960. 9. Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI, Zhao RC, Shi Y: Mesenchymal stem cell-mediated immunosuppression happens via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008, 2:14150. 10. Aggarwal S, Pittenger MF: Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005, 105:1815822. 11. Maccario R, Podesta M, Moretta A, Cometa A, Comoli P, Montagna D, Daudt L, Ibatici A, Piaggio G, Pozzi S, Frassoni F, Locatelli F: Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype. Haematologica 2005, 90:51625. 12. Selmani Z, Naji A, Zidi I, Favier B, Gaiffe E, Obert L, Borg C, Saas P, Tiberghien P, Rouas-Freiss N, Carosella ED, Deschaseaux F: Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is necessary to suppress T lymphocyte and natural killer function and to induce CD4 + CD25highFOXP3+ regulatory T cells.IL-4 Protein, Human Stem Cells 2008, 26:21222.PMID:36014399 13. Mougiakakos D, Jitschin R, Johansson CC, Okita R, Kiessling R, le Blanc K: The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells. Blood 2011, 117:4826835. 14. Gonzalez-Rey E, Anderson P, Gonzalez MA, Rico L, Buscher D, Delgado M: Human adult stem cells derived from adipose tissue shield against experimental colitis and sepsis. Gut 2009, 58:92939. 15. Carrion F, Nova E, Ruiz C, Diaz F, Inostroza C, Rojo D, Monckeberg G, Figueroa FE: Autologous mesenchymal stem cell remedy increased T regulatory cells with no effect on illness activity in two systemic lupus erythematosus patients. Lupus 2010, 19:31722. 16. Perico N, Casiraghi F, Introna M, Gotti E, Todeschini M, Cavinato RA, Capelli C, Rambaldi A, Cassis P, Rizzo P, Cortinovis M, MarasM, Golay J, Noris M, Remuzzi G: Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility. Clin J Am Soc Nephrol 2011, 6:41222. 17. Lafaille JJ: The part of helper T cell subsets in autoimmune diseases. Cytokine Development Factor Rev 1998, 9:13951. 18. Bettelli E, Oukka M, Kuchroo VK: T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007, eight:34550.Conclusion Taken together, these data demonstrate that MSCs are in a position to induce functional Treg cells throughout the differentiation method of Th1 and Th17 cells. The generation of.

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