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LSCC could be the most common head and neck squamous cell carcinoma (HNSCC).1 Despite current advances in oncological and surgical remedies, the prognosis of advanced LSCC remains particularly poor.PMID:23460641 two Hence, chemotherapy becomes anideal adjuvant remedy for LSCC. Cisplatin (CDDP) as a rstline agent or aer getting combined with paclitaxel or carboplatin has been utilised for LSCC therapy.3,4 On the other hand, the extreme adverse reactions of systemic chemotherapy are unavoidable as a result of poor chemosensitivity and improved cytotoxicity effects on account of multidrug combinations.5 Consequently, the crucial point to improve the prognosis of LSCC is the improvement offaShanxi Crucial Laboratory of Otorhinolaryngology Head and Neck Cancer, Initially Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China. E-mail: [email protected]; [email protected] Division of Otolaryngology Head Neck Surgery, Initial Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, ChinaDepartment of Otolaryngology Head Neck Surgery, Dalian Municipal Friendship Hospital, Dalian 116001,.