De Barcelona, Barcelona, Spain. 10 Departament de Medicina, Universitat Aut oma deDe Barcelona, Barcelona, Spain.

De Barcelona, Barcelona, Spain. 10 Departament de Medicina, Universitat Aut oma de
De Barcelona, Barcelona, Spain. 10 Departament de Medicina, Universitat Aut oma de Barcelona, Barcelona, Spain. 11Servei de Pneumologia, ALK3 web Hospital de Bellvitge, Feixa Llarga s/n, 08907L Hospitalet de Llobregat, Spain. 12IDIBELL (Institut d’InvestigaciBiom ica de Bellvitge), Gran By means of de L’Hospitalet 199, 08908 Hospitalet de Llobregat, Spain. 13Arizona Respiratory Center, Tucson, AZ, USA. 14Servei de Pneumologia, Hospital Universitari Son Espases, Carretera de Valldemosa 79, 07010 Palma de Mallorca, Spain. 15Institut de InvestigaciSanit ia de Palma (IdISPa), Carretera de Valldemossa 79, Palma, Spain. 16Thorax Institute, Hospital Cl ic, Barcelona, Spain. 17Institut d’InvestigaciBiom ica AgustPi I Sunyer (IDIBAPS), Barcelona, Spain. 18Universitat de Barcelona, Barcelona, Spain. 19FundaciInvestigaciSanit ia Illes Balears (FISIB), Palma de Mallorca, Spain. Received: four January 2015 Accepted: eight January 2015 Published: 17 January 2015 References 1. Lopez AD, Shibuya K, Rao C, Mathers CD, Hansell AL, Held LS, et al. Chronic obstructive pulmonary illness: current burden and future projections. Eur Respir J. 2006;27:39712. 2. Murray CJ, L ez AD. Measuring the Worldwide Burden of Illness. N Engl J Med. 2013;369:4487. three. Coultas DB, Mapel D, Gagnon R, Lydick E. The overall health effect of undiagnosed airflow obstruction within a national sample of United states adults. Am J Respir Crit Care Med. 2001;164:372. 4. Rennard S, Decramer M, Calverley PM, Pride NB, Soriano JB, Vermeire PA, et al. Influence of COPD in North America and Europe in 2000: subjects’ perspective of Confronting COPD International Survey. Eur Respir J. 2002;20:79905. 5. Soriano JB, Ancochea J, Miravitlles M, Garc -R F, Duran-Tauleria E, Mu z L, et al. Akt1 site Recent trends in COPD prevalence in Spain: a repeated cross-sectional survey 1997007. Eur Respir J. 2010;36:7585. six. Soriano JB, Miravitlles M, Border s L, Duran-Tauleria E, Garc R F, Mart ez J, et al. Geographical variations inside the prevalence of COPD in Spain: Connection to Smoking, Death Prices and other Determining Elements. Arch Bronconeumol. 2010;46:5220. 7. Bednarek M, Maciejewski J, Wozniak M, Kuca P, Zielinski J. Prevalence, severity and underdiagnosis of COPD inside the major care setting. Thorax. 2008;63:402. eight. Jordan RE, Lam KB, Cheng KK, Miller MR, Marsh JL, Ayres JG, et al. Case finding for chronic obstructive pulmonary illness: a model for optimising a targered strategy. Thorax. 2010;65:492. 9. Miravitlles M, Soriano JB, Garc -R F, Mu z L, Duran-Tauleria E, Sanchez G, et al. Prevalence of COPD in Spain: effect of undiagnosed COPD on high-quality of life and everyday life activities. Thorax. 2009;64:863. ten. Soriano JB, Zielinski J, Cost D. Screening for and early detection of chronic obstructive pulmonary disease. Lancet. 2009;374:7212. 11. Zoia MC, Corsico AG, Beccaria M, Guarnone R, Cervio G, Testi R, et al. Exacerbations as a beginning point of pro-active chronic obstructive pulmonary illness management. Respir Med. 2005;99:15685. 12. Bastin AJ, Starling L, Ahmed R, Dinham A, Hill N, Stern M, et al. High prevalence of undiagnosed and extreme chronic obstructive pulmonary disease initially hospital admission with acute exacerbation. Chron Respir Dis. 2010;7:91. 13. Garcia-Aymerich J, G ez FP, AntJM. Phenotypic characterization and course of chronic obstructive pulmonary disease (COPD) within the PAC-COPD Study: design and approaches. Arch Bronconeumol. 2009;45:41. 14. BarberJA, Peces-Barba G, AgustAG, Izquierdo JL, MonsE, Montemayor T, et al. Clinical.