nds using a superior antioxidant capacity, which is directly associated to the phytochemical content. A.

nds using a superior antioxidant capacity, which is directly associated to the phytochemical content. A. hierochuntica (especially aqueous extract) protects rats against CCl4 -induced oxidative anxiety and acute kidney injury, as evidenced by a important drop in MDA levels and enhanced GSH and SOD activity, as well because the cessation of biochemical and histological alterations within the kidneys. The protective efficacy could arise in the antioxidant and absolutely free radical scavenging properties in the phenolic compounds present inside the A. hierochuntica extracts. These characteristics aid to clarify the plant’s medicinal efficacy as a herbal medication. Additional study is needed to totally describe the active principles in a. hierochuntica, and this study is meant to stimulate much more complete related investigation to offer adequate information and suggestions for defining its mechanisms and safe doses.Author Contributions: Conceptualization, T.I.A., Y.M.A. and H.B.; Caspase 1 web methodology, investigation, H.B. and H.A.A.-R.; data curation, T.I.A. and Y.M.A.; writing–original draft CB2 Molecular Weight preparation, evaluation,Nutrients 2021, 13,13 ofand editing; H.B. and H.A.A.-R. All authors have read and agreed towards the published version of your manuscript. Funding: The researchers would prefer to thank the Deanship of Scientific Study, Qassim University, for funding the publication of this project. Institutional Review Board Statement: Not applicable. Informed Consent Statement: Not applicable. Data Availability Statement: The information presented in this study are accessible on request from the corresponding author. Conflicts of Interest: The authors declare no conflict of interest.AbbreviationsABTS: two,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid); AOA: antioxidant activity; BHA: butylated hydroxyanisole; BHA: butylated hydroxyanisole; DPPH: 1,1-diphenyl-2-picryl hydrazine; dw: dry weight; GA: gallic acid; GAE: gallic acid equivalent; GSH: reduced-glutathione; HPLC-DAD: high-performance liquid chromatography diode array detection; KAE: A. hierochuntica aqueous extract; KEE: A. hierochuntica ethanolic extract; MDA: malonaldehyde; QE: quercetin equivalent; RAA: relative antioxidant activity; ROS: reactive oxygen species; RSA: radical scavenging activity; Se: selenium; SE: standard error; SOD: superoxide dismutase; TC: total carotenoids; TC: total carotenoids; TF: total flavonoids; TE: trolox equivalents; TFL: total flavonols; TPC: total phenolic compounds.
Received: 25 October 2021 Accepted: 15 November 2021 Published: 17 NovemberPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access short article distributed below the terms and situations with the Creative Commons Attribution (CC BY) license ( creativecommons.org/licenses/by/ four.0/).Cancer is really a leading cause of death worldwide, accounting for almost 10 million deaths in 2020. Among the techniques which have been developed to treat cancer, chemotherapy is made use of mainly to treat metastatic cancer that can’t be eradicated with surgery or radiotherapy. Despite the fact that chemotherapy would be the most productive method to eradicate cancer, it entails quite a few challenges for example evolution of multidrug resistance (MDR) in cancer cells, which involves altered drug activation because of metabolism and excretion, and increased repair of DNA harm triggered by anti-cancer drugs. The main mechanism underlying MDR is