varian follicle improvement (GO:0001541) Progesterone receptor signaling pathway (GO:0050847); Progesterone-mediated oocyte maturation (hsa04914); Oocyte meiosis

varian follicle improvement (GO:0001541) Progesterone receptor signaling pathway (GO:0050847); Progesterone-mediated oocyte maturation (hsa04914); Oocyte meiosis (hsa04114) Circadian sleep/wake cycle, REM sleep (GO:0042747); Ovarian steroidogenesis (hsa04913) Progesterone metabolic process (GO:0042448) GO:0006700 C21-steroid hormone biosynthetic process; Ovarian steroidogenesis (hsa04913) Constructive regulation of estradiol secretion (GO:2000866); Damaging regulation of macrophage chemotaxis (GO:0010760) Intracellular estrogen receptor signaling pathway (GO:0030520) Negative regulation of follicle-stimulating hormone secretion (GO:0046882); Optimistic regulation of follicle-stimulating hormone secretion (GO:0046881) Cellular response to luteinizing hormone stimulus (GO:0071373) VEGF signaling pathway (hsa04370) Log fold transform 3.9 1.MOV10L1 Mov10 like RISC complicated RNA helicase 1 DDX4 Dead-box helicaseBLM CENPSBLM RecQ like helicase Centromere protein S2.1 1.XRCC3 FANCD2 CDC42 BUBX-ray repair cross complementing FA complementation group D2 Coiled-coil domain PDE2 Source containing 42 BUB1 mitotic checkpoint serine/threonine kinase2.1 1.8 ten 1.LHX8 NOBOX SOHLHLIM homeobox eight NOBOX oogenesis homeobox spermatogenesis and oogenesis certain basic helix-loop-helix10 11 8.Foxl2 FSHR PGRforkhead box L2 Receptor for follicle stimulating hormone Progesterone XIAP Purity & Documentation receptor4.8 2.9 1.STARSteroidogenic acute regulatory protein2.2 four.1 2.four 9.five two.7 two.five 1.3 two.CYP17A1 Cytochrome P450 loved ones 17 subfamily A member 1 CYP11A1 Cytochrome P450 household 11 subfamily A member 1 CYP19A1 Cytochrome P450 family 19 subfamily A member 1 ESR2 INHBA LHCGR VEGF-A Estrogen receptor two Inhibin subunit beta A Luteinizing hormone/choriogonadotropin receptor Vascular endothelial development issue A0001568); the enriched terms full list within the up-regulated genes with their respective log10 (p-values) is in More file eight. In Added file 9, a subset of these enriched terms is pictured inside a distinct viewpoint to show the connections among processes, a node pictures each term, where its size is proportional for the number of genes belonging to this termparison between the supplemented infected vs manage infected groupsWe analysed the full lists of genes differentially expressed within the comparison Supplemented Infected vs Control Infected to seek out the enriched pathways in the ewe lambs’ ovary as a consequence of the distinction of protein’s level in the diet plan inside the presence of an infection. TheSuarez-Henriques et al. BMC Veterinary Study(2021) 17:Page 9 ofFig. three Prevalent and distinct up-regulated processes in between Supplemented not Infected vs Manage not Infected and Supplemented Infected vs Control Infected. The processes that have been discovered enriched in popular inside the two comparisons are represented within the intersection of the two circlesMetascape software program identified 2187 gene identifiers, 2187 human Entrez Gene IDs. Among other biological processes and pathways enriched in the up-regulated genes list, we identified: Meiotic nuclear division (GO:0140013), Female gamete generation (GO:0007292), Double-strand break repair via break-induced replication (GO: 0000727), HDR via Homologous recombination(R-HSA-5685942), DNA biosynthetic procedure (GO:0071897), Oocyte meiosis (hsa04114), Establishment of Chromosome localisation (GO:0051303), Methylation (GO: 0032259), DNA conformation adjust (GO:0071103), Hallmark E2F targets (M5925), DNA – dependent DNA replication (GO: 0006261), DNA replication (R-HSA-69306), Ribosome biogenesis