B ahead of print] 3. Bottiroli S, Viana M, Sances G, et al. Psychological variables

B ahead of print] 3. Bottiroli S, Viana M, Sances G, et al. Psychological variables connected to failure of detoxification treatment in chronic Arachidic acid Biological Activity Headache related with medication overuse. Cephalalgia 2016; 36: 1356-1365. 4. Tassorelli C, Jensen R, Allena M, De Icco R, Sances G, Katsarava Z, Lainez M, Leston J, Fadic R, Spadafora S, Pagani M, Nappi G; the COMOESTAS Consortium. A consensus protocol for the management of medicationoveruse headache: Evaluation within a multicentric, multinational study. Cephalalgia. 2014 Aug; 34(9):645-655.S57 Chronic Headaches Cefalee Croniche Grazia Sances1, Sara Bottiroli1, Michele Viana1, Natascia Ghiotto1, Elena Guaschino1, Marta Allena1, Cristina Tassorelli1-2 1 Headache Science Center (HSC), C. Mondino National Institute of Neurology Foundation, Pavia, Italy; 2Dept of Brain and Behavioural Sciences, University of Pavia, Italy Correspondence: Grazia Sances ([email protected]) The Journal of Headache and Pain 2017, 18(Suppl 1):S57 Chronic headaches are a relevant overall health challenge characterized by substantial disability, poor high-quality of life and high 991 Inhibitors targets economic burden (1). The most widespread forms contain chronic migraine (CM) and medication overuse headache (MOH), which are often connected, provided that the majority of CM sufferers do overuse acute medicines (CM with MO). Chronic headaches represent a challenge for physicians, provided their frequent resistance to therapies, threat of relapse and connected comorbidities. Their management incorporates a number of actions aimed to: 1) make a right diagnosis excluding secondary types; two) identify exacerbating elements; three) treat comorbidities; four) determine and address medication overuse; five) establish a therapeutic agreement with patient; six) define an integrated care approach. Patienthistory collection is important for defining headache onset and its lifelong course, chronicization aspects, and outcomes of earlier therapies (acute and prophylactic). Overused drug discontinuation would be the 1st strategy for MOH and it can be achieved by way of multiple modalities – in-patient or out-patient withdrawal procedures, guidance alone depending on many headache-associated or patient-associated variables. For the duration of withdrawal, sufficient care is required to help the patient to go through the remedy phases, offered the frequent occurrence of headache recrudescence. Headache diaries represent beneficial tools in monitoring attacks frequency, detecting medication overuse, checking therapies outcomes, and assessing disability improvements. A relevant trouble in MOH may be the danger of relapse into overuse just after prosperous withdrawal. You’ll find only handful of controlled pharmacological trials on the management of MO in CM, which does not enable to derive precise figures around the risk of relapse into MO connected to specific therapies. In addition, theS58 Headache in the elderly Carlo Lisotto Headache Centre, Department of Neurology, Azienda Sanitaria Friuli Occidentale, Pordenone, Italy The Journal of Headache and Discomfort 2017, 18(Suppl 1):S58 Background Headache prevalence is age-dependent and decreases progressively over time, specially beginning in the age of 55-60. The incidence of major headaches declines, whereas secondary headaches tend to take place extra frequently with rising age [1]. Although the prevalence of headache within the elderly is relevant, handful of research have already been conducted in individuals more than 65 so far. Materials and Methods The clinical records of 9075 consecutive outpatients aged more than 18 referred to.