product name Zinc Pyrithione
Description: Zinc pyrithione (also known as OM-1563) is an antifungal and antibacterial agent that disrupts membrane transport by blocking the proton pump. Zinc pyrithione is considered as a coordination complex of zinc structurally. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers.
References: Appl Environ Microbiol. 1995 Sep;61(9):3385-90; Environ Toxicol Chem. 2010 Nov;29(11):2583-92.
317.7
Formula
C10H8N2O2S2Zn
CAS No.
13463-41-7
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 30 mg/mL (94.4 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
OM-1563
other peoduct :
| In Vitro |
In vitro activity: Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM. Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Zinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50) = 8.27 μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed. |
| Animal model | |
| Formulation & Dosage | |
| References | Appl Environ Microbiol. 1995 Sep;61(9):3385-90; Environ Toxicol Chem. 2010 Nov;29(11):2583-92. |
