product name Vinorelbine Tartrate
Description: Vinorelbine is an anti-mitotic chemotherapy drug that is used for the treatment for some types of cancer, including breast cancer and non-small cell lung cancer. Vinorelbine blocks cell cycle progression in mitosis with IC50 of 3.8 nM, which is only slightly higher than the IC50 value for inhibition of proliferation, indicating that mitotic block is a major contributor to antiproliferative action.
References: Semin Oncol. 1989 Apr;16(2 Suppl 4):9-14; Eur J Cancer. 1999 Mar;35(3):512-20.
1079.11
Formula
C45H54N4O8.2C4H6O6
CAS No.
125317-39-7
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (92.7 mM)
Water: 100 mg/mL (92.7 mM)
Ethanol: 100 mg/mL (92.7 mM)
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. |
| Animal model | Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts. |
| Formulation & Dosage | Dissolved in Sterile 0.9% sodium chloride solution; 10 mg/kg; i.p. injection |
| References | Semin Oncol. 1989 Apr;16(2 Suppl 4):9-14; Eur J Cancer. 1999 Mar;35(3):512-20. |
