product name Verapamil HCl
Description: Verapamil is an L-type calcium channel blocker in the phenylalkylamine class. Verapamil hydrochloride blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage.
References: Drug Metab Pharmacokinet. 2013;28(6):468-74; PLoS One. 2013 Aug 12;8(8):e71567.
491.06
Formula
C27H38N2O4.HCl
CAS No.
152-11-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 98 mg/mL (199.6 mM)
Water: 50 mg/mL (101.8 mM)
Ethanol: 12 mg/mL (24.4 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19403500
| In Vitro |
In vitro activity: The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively). Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart. |
| Animal model | |
| Formulation & Dosage | |
| References | Drug Metab Pharmacokinet. 2013;28(6):468-74; PLoS One. 2013 Aug 12;8(8):e71567. |
Related Posts
product name Verapamil HCl
Description: Verapamil is an L-type calcium channel blocker in the phenylalkylamine class. Verapamil hydrochloride blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage.
References: Drug Metab Pharmacokinet. 2013;28(6):468-74; PLoS One. 2013 Aug 12;8(8):e71567.
491.06
Formula
C27H38N2O4.HCl
CAS No.
152-11-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 98 mg/mL (199.6 mM)
Water: 50 mg/mL (101.8 mM)
Ethanol: 12 mg/mL (24.4 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19403500
| In Vitro |
In vitro activity: The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively). Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart. |
| Animal model | |
| Formulation & Dosage | |
| References | Drug Metab Pharmacokinet. 2013;28(6):468-74; PLoS One. 2013 Aug 12;8(8):e71567. |