product name VPS34 inhibitor 1
Description: VPS34 inhibitor 1 (also known as Vps34-IN1, Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM. It does not significantly inhibit the activity of over 340 additional kinases, including class I and II PI3Ks. Vps34-IN1 induces a rapid dose-dependent dispersal of a specific PtdIns-(3)-P-binding probe from endosome membranes, within one minute, without affecting the ability of class I PI3K to regulate Akt.
References: ACS Med Chem Lett. 2015 Nov 13;7(1):72-6.
391.47
Formula
C21H25N7O
CAS No.
1383716-46-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 78 mg/mL (199.2 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: VPS34 inhibitor 1 (Vps34-IN1, Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM. It does not significantly inhibit the activity of over 340 additional kinases, including class I and II PI3Ks. Vps34-IN1 induces a rapid dose-dependent dispersal of a specific PtdIns-(3)-P-binding probe from endosome membranes, within one minute, without affecting the ability of class I PI3K to regulate Akt. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | ACS Med Chem Lett. 2015 Nov 13;7(1):72-6. |
