product name VGX-1027
Description: VGX-1027 (also known as GIT 27) is an orally active, isoxazoline compound with potent immunomodulatory properties. VGX-1027 significantly inhibits both IL-1β/IFN-γ-induced TNF-α and nitrite accumulation, and causes a significant increase in cell survival by interfering with the cytotoxic effects of the cytokines. In microarray analysis, VGX-1027 modulated the expression of genes that involved in immune activation and the antigen processing and presentation in response to lipopolysaccharide (LPS) stimulation.
References: J Pharmacol Exp Ther. 2007 Mar;320(3):1038-49; Eur J Pharmacol. 2008 May 31;586(1-3):313-21.
205.21
Formula
C11H11NO3
CAS No.
6501-72-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 41 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: 41 mg/mL (199.8 mM)
Solubility (In vivo)
2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 10mg/mL
Synonyms
GIT 27
other peoduct :
| In Vitro |
In vitro activity: VGX-1027 significantly inhibits both IL-1β/IFN-γ-induced TNF-α and nitrite accumulation, and causes a significant increase in cell survival by interfering with the cytotoxic effects of the cytokines. VGX-1027 inhibits both proliferation of enterobacterial antigen-reactive CD4+CD25− T cells in vitro. Kinase Assay: Cell Assay: In microarray analysis, VGX-1027 modulated the expression of genes that involved in immune activation and the antigen processing and presentation in response to lipopolysaccharide (LPS) stimulation. In CD4+CD25− T cells, VGX-1027 inhibited cell proliferation induced by enterobacterial antigen. |
|---|---|
| In Vivo | VGX-1027 prevents development of spontaneous type 1 diabetes in NOD Mice and counteracts accelerated diabetogenesis induced by cyclophosphamide challenge or adoptive transfer of diabetogenic spleen cells in NOD Mice. VGX-1027 also reduces clinical signs of MLD-STZ-induced diabetes and suppresses pathohistological changes of pancreas. VGX-1027 suppresses the development of clinical, histological and immunological signs of DNBS-induced colitis in CD1 mice. In NZB/NZW F1 model of systemic lupus erythematosus (SLE), VGX-1027 ameliorates the course of the disease with higher percent survival and improved clinical and histopathological signs. |
| Animal model | NOD Mice with MLD-STZ-induced diabetes |
| Formulation & Dosage | Dissolved in 500 mM Na2HPO4; 20 mg/kg b.wt. i.p. and 100 mg/kg b.wt. p.o.; i.p. or p.o. |
| References | J Pharmacol Exp Ther. 2007 Mar;320(3):1038-49; Eur J Pharmacol. 2008 May 31;586(1-3):313-21. |
