product name UMI-77
468.34
Formula
C18H14BrNO5S2
CAS No.
518303-20-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 93 mg/mL (198.6 mM)
Water: <1 mg/mL (slightly soluble or insoluble)
Ethanol: Not available
Solubility (In vivo)
5% DMSO+30% PEG 300+dd H2O: 6 mg/mL
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1940023
| General | In a BxPC-3 xenograft mouse model, UMI-77 (60 mg/kg i.v.) exhibits single-agent antitumor activity without any damage normal tissues |
|---|---|
| Animal model | Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells. |
| Formulation | Obatoclax (tartrate salt) is formulated in 9.6% PEG300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated in 9.48% PEG, 0.38% polysorbate 20. |
| Dosages | 0.0313, 0.25, 0.5 and 2 mg/kg |
| Administration | Intravenously (tail vein) once a day |
| Reference | [1] Abulwerdi F, et al. Mol Cancer Ther. 2014, 13(3), 565-575. |
Related Posts
product name UMI-77
468.34
Formula
C18H14BrNO5S2
CAS No.
518303-20-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 93 mg/mL (198.6 mM)
Water: <1 mg/mL (slightly soluble or insoluble)
Ethanol: Not available
Solubility (In vivo)
5% DMSO+30% PEG 300+dd H2O: 6 mg/mL
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1940023
| General | In a BxPC-3 xenograft mouse model, UMI-77 (60 mg/kg i.v.) exhibits single-agent antitumor activity without any damage normal tissues |
|---|---|
| Animal model | Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells. |
| Formulation | Obatoclax (tartrate salt) is formulated in 9.6% PEG300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated in 9.48% PEG, 0.38% polysorbate 20. |
| Dosages | 0.0313, 0.25, 0.5 and 2 mg/kg |
| Administration | Intravenously (tail vein) once a day |
| Reference | [1] Abulwerdi F, et al. Mol Cancer Ther. 2014, 13(3), 565-575. |