product name Tretinoin
Description: Tretinoin (also known as All-trans Retinoic Acid), a naturally-occurring acid of retinol and a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells. Tretinoin binds to and activates retinoic acid receptors, thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types.
References: J Pharmacol Exp Ther. 1999 Apr;289(1):123-32; J Invest Dermatol. 1994 Feb;102(2):241-6.
300.4
Formula
C20H28O2
CAS No.
302-79-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 60 mg/mL (199.7 mM)
Water: <1 mg/mL
Ethanol: 6 mg/mL (20.0 mM)
Solubility (In vivo)
Synonyms
All-trans Retinoic Acid
other peoduct :
| In Vitro |
In vitro activity: Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. Kinase Assay: Cell Assay: In cultured human mesangial cells, tretinoin increased the reduced glutathione content and the catalase activity in a dose- and time-dependent way, which then prevented the cytotoxicity of H2O2 |
|---|---|
| In Vivo | Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished |
| Animal model | male Fischer 344 rats |
| Formulation & Dosage | |
| References | J Pharmacol Exp Ther. 1999 Apr;289(1):123-32; J Invest Dermatol. 1994 Feb;102(2):241-6. |
