product name Tolperisone HCl
Description: Tolperisone HCl is an ion channel blocker and centrally-acting muscle relaxant. Tolperisone reduces sodium and potassium permeability in the node of Ranvier of frogs, blocks calcium currents in snail neurons and inhibits current through heterologously expressed Nav1.6 channels. Tolperisone hydrochloride represents an effective and safe treatment of painful reflex muscle spasm without the typical side effects of centrally active muscle relaxants.
References: Eur J Pharmacol. 2006 May 24;538(1-3):5-14; Pain. 1996 Oct;67(2-3):417-25.
281.82
Formula
C16H23NO.HCl
CAS No.
3644-61-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 56 mg/mL (198.7 mM)
Water: 56 mg/mL (198.7 mM)
Ethanol: 56 mg/mL (198.7 mM)
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Tolperisone reduces sodium and potassium permeability in the node of Ranvier of frogs, blocks calcium currents in snail neurons and inhibits current through heterologously expressed Nav1.6 channels. Tolperisone hydrochloride represents an effective and safe treatment of painful reflex muscle spasm without the typical side effects of centrally active muscle relaxants. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Eur J Pharmacol. 2006 May 24;538(1-3):5-14; Pain. 1996 Oct;67(2-3):417-25. |
