product name Tolfenamic Acid
Description: Tolfenamic Acid, also known as Clotam, is a COX-2 inhibitor with IC50 of 0.2 μM. Tolfenamic acid is used as a non-steroidal anti-inflammatory drug (NSAIDs). Tolfenamic acid acts by interferring with the synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. Tolfenamic acid has been reported to exhibit anti-cancer activities in several types of cancer.
References: Int Immunopharmacol. 2016 Jun;35:287-93; J Neurochem. 2015 Apr;133(2):266-72.
261.7
Formula
C14H12ClNO2
CAS No.
13710-19-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 52 mg/mL (198.7 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19407859
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