product name Terbutaline Sulfate
Description: Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 NM, it has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma.
References: Allergy. 1984 Jul;39(5):351-7; Int J Clin Pharmacol Ther Toxicol. 1992 Sep;30(9):342-62.
548.65
Formula
C24H38N2O6.H2O4S
CAS No.
23031-32-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: <1 mg/mL
Water: 100 mg/mL (182.3 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19398310
| In Vitro |
In vitro activity: Terbutaline is a relatively selective β2-adrenergic bronchodilator that has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma. Terbutaline also shows competitive reversible inhibition for all BChE variants. The dissociation constants for UU, FF and AA homozygotes are 0.18, 0.31 and 3.3 mM, respectively. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Terbutaline appears to have a greater stimulating effect on beta-receptors of the bronchial, vascular, and uterine smooth muscles (β2 receptors) than on the beta-receptors of the heart (β1 receptors). This drug relaxes smooth muscle and inhibits uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation. |
| Animal model | |
| Formulation & Dosage | |
| References | Allergy. 1984 Jul;39(5):351-7; Int J Clin Pharmacol Ther Toxicol. 1992 Sep;30(9):342-62. |
Related Posts
product name Terbutaline Sulfate
Description: Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 NM, it has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma.
References: Allergy. 1984 Jul;39(5):351-7; Int J Clin Pharmacol Ther Toxicol. 1992 Sep;30(9):342-62.
548.65
Formula
C24H38N2O6.H2O4S
CAS No.
23031-32-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: <1 mg/mL
Water: 100 mg/mL (182.3 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19398310
| In Vitro |
In vitro activity: Terbutaline is a relatively selective β2-adrenergic bronchodilator that has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma. Terbutaline also shows competitive reversible inhibition for all BChE variants. The dissociation constants for UU, FF and AA homozygotes are 0.18, 0.31 and 3.3 mM, respectively. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Terbutaline appears to have a greater stimulating effect on beta-receptors of the bronchial, vascular, and uterine smooth muscles (β2 receptors) than on the beta-receptors of the heart (β1 receptors). This drug relaxes smooth muscle and inhibits uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation. |
| Animal model | |
| Formulation & Dosage | |
| References | Allergy. 1984 Jul;39(5):351-7; Int J Clin Pharmacol Ther Toxicol. 1992 Sep;30(9):342-62. |