product name Teniposide
Description: Teniposide (also known as NSC 122819, VM-26) is a chemotherapeutic agent mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). It acts by forming a ternary complex with the enzyme topoisomerase II and DNA, which results in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. Teniposide acts in the late S or early G phase of the cell cycle.
References: Nucleic Acids Res. 1987 Apr 24;15(8):3455-68.
656.65
Formula
C32H32O13S
CAS No.
29767-20-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 40 mg/mL (60.9 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
NSC 122819, VM-26
other peoduct :
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In vitro activity: Kinase Assay: Cell Assay: |
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