product name Sulfameter
Description: Sulfameter is a long-acting sulfonamide antibacterial used as a leprostatic agent and to treat urinary tract infections. Sulfonamide antibiotics block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. The mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
References: Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):260-3; Clin Pharmacol Ther. 1969 Jul-Aug;10(4):591-4.
280.3
Formula
C11H12N4O3S
CAS No.
651-06-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 56 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19410601
| In Vitro |
In vitro activity: Sulfameter(Bayrena) is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent in the treatment of urinary tract infections. Six physically healthy patients each were given 2 g of sulfameter simultaneously with a high lipid, high protein and high carbohydrate test meal. This experiment was designed as a threefold crossover study, and there was a randomized assignment of patients to the different conditions. The results show that sulfameter is significantly better absorbed when administered with a high lipid meal than when given with a high protein or high carbohydrate meal, demonstrated by the areas under the serum concentration curves (AUC), by the peak serum concentration and by the cumulative renal excretion. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):260-3; Clin Pharmacol Ther. 1969 Jul-Aug;10(4):591-4. |
