product name Sodium Danshensu
Description: Sodium Danshensu is the sodium salt of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza. Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical scavenger and antioxidant which exhibits higher scavenging activities against free hydroxyl radicals, superoxide anion radicals.
References: Food Chem Toxicol. 2008 Jan;46(1):73-81; Toxicol Mech Methods. 2010 Oct;20(8):510-4.
220.15
Formula
C9H9O5.Na
CAS No.
67920-52-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 7 mg/mL (31.8 mM)
Water: 2 mg/mL (9.1 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical scavenger and antioxidant which exhibits higher scavenging activities against free hydroxyl radicals (HO()), superoxide anion radicals (O(2)(-)), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and 2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals than vitamin C. Sodium danshensu shows a biphasic effects on vessel tension. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of sodium danshensu produces a weak contraction, while high concentrations (1-3 g/L) produces a pronounced vasodilator after a transient vasocontraction. Pre-incubation with sodium danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium danshensu also inhibits phenylephrine- and CaCl2-induced vasoconstriction in Ca(2+)-free medium. Kinase Assay: Cell Assay: |
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| In Vivo | Thoracic aortae from normal rats were isolated and equilibrated in organ bath with Krebs-Henseleit buffer and ring tension was recorded. Effects of sodium danshensu on basal tonus of the vessel and its effects on vessel contraction and relaxation with or without endothelium were observed. |
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| Formulation & Dosage | |
| References | Food Chem Toxicol. 2008 Jan;46(1):73-81; Acta Pharmacol Sin. 2010 Apr;31(4):421-8; Toxicol Mech Methods. 2010 Oct;20(8):510-4. |
