product name Salubrinal
References: Science, 2005, 307(5711), 935-939.; Am J Physiol Regul Integr Comp Physiol, 2009, 296(1), 178-184.
479.81
Formula
C21H17Cl3N4OS
CAS No.
405060-95-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 96 mg/mL (200.07 mM)
Water: <1 mg/mL (slightly soluble or insoluble)
Ethanol: 2 mg/mL (4.16 mM)
Solubility (In vivo)
Chemical Name
(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide
other peoduct :
| Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. | |
|---|---|
| In Vivo | Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. |
| Animal model | Eight-week-old male CD-1 outbred mice |
| Formulation & Dosage | DMEM; 75μM; On cornea |
| References | [1] Boyce M, et al. Science, 2005, 307(5711), 935-939. |
