product name Rotigotine
Description: Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinsons disease and restless legs syndrome. Rotigotine is dopamine D2 and D3 receptor agonist with Ki values of 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic α2B receptors.
References: Curr Med Res Opin. 2016;32(1):77-85.
315.47
Formula
C19H25NOS
CAS No.
99755-59-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 63 mg/mL (199.7 mM)
Water: <1 mg/mL
Ethanol: 63 mg/mL (199.7 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19414035
| In Vitro |
In vitro activity: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic α2B receptors. Rotigotine exhibits antiparkinsonian acitivity. Kinase Assay: Cell Assay: |
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| In Vivo | |
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| Formulation & Dosage | |
| References |
