product name Rosiglitazone HCl
Description: Rosiglitazone HCl, the hydrochloric salt of Rosiglitazone, is a blood glucose-lowering drugs that stimulate insulin secretion by binding to the PPAR receptors in fat cells. Rosiglitazone is the thiazolidinedione class of antidiabetic drugs. It works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.
References: Obes Rev. 2015 Jun;16(6):498-507.
393.89
Formula
C18H19N3O3S.HCl
CAS No.
302543-62-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 79 mg/mL (200.6 mM)
Water: <1 mg/mL
Ethanol: 79 mg/mL (200.6 mM)
Solubility (In vivo)
Synonyms
BRL-49653 HCl
other peoduct :
| In Vitro |
In vitro activity: Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | For therapeutic studies, predictive validity of animal models – arguably the most important feature of animal models in terms of human relevance – can be calculated retrospectively by obtaining data on treatment efficacy from human and animal trials. Using rosiglitazone as a case study, we aim to determine the predictive validity of animal models of diabetes, by analysing which models perform most similarly to humans during rosiglitazone treatment in terms of changes in standard diabetes diagnosis parameters (glycosylated haemoglobin [HbA1c] and fasting glucose levels). A further objective of this paper was to explore the impact of four covariates on the predictive capacity: (i) diabetes induction method; (ii) drug administration route; (iii) sex of animals and (iv) diet during the experiments. Despite the variable consistency of animal species-based models with the human reference for glucose and HbA1c treatment effects, our results show that glucose and HbA1c treatment effects in rats agreed better with the expected values based on human data than in other species. Induction method was also found to be a substantial factor affecting animal model performance. The study concluded that regular reassessment of animal models can help to identify human relevance of each model and adapt research design for actual research goals. |
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| Formulation & Dosage | |
| References | Obes Rev. 2015 Jun;16(6):498-507. |
