product name (R)-baclofen
Description: (R)-baclofen (also known as STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission. GABAB receptors are metabotropic receptors which produce slow inhibitory signals.
References: J Neurochem. 1986 Sep;47(3):898-903; Lancet. 1984 May 12;1(8385):1078.
213.66
Formula
C10H12ClNO2
CAS No.
69308-37-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 8 mg/mL (37.4 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
STX 209
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19422061
| In Vitro |
In vitro activity: Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | J Neurochem. 1986 Sep;47(3):898-903; Lancet. 1984 May 12;1(8385):1078. |
