product name Quinapril HCl
Description: Quinapril HCl (also known as CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM. Quinapril is a prodrug that is converted to its active metabolite, quinaprilat. Quinaprils target, ACE, catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a potent vasoconstrictor and thus preventing its formation causes vasodilation and an increased capillary blood volume.
References: Cardiovasc Drugs Ther. 2002 Jan;16(1):29-36; Drugs. 2002;62(2):339-85.
474.98
Formula
C25H30N2O5.HCl
CAS No.
82586-55-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 95 mg/mL (200.0 mM)
Water: 95 mg/mL (200.0 mM)
Ethanol: 95 mg/mL (200.0 mM)
Solubility (In vivo)
Synonyms
CI-906, PD-109452-2
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