product name Puerarin
Description: Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. Pueraria is employed clinically to treat cardiovascular diseases in China. Another study showed that puerarin also possessed anti-cancer properties. Puerarin at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2.
References: Pharmacol Biochem Behav. 2003 Jun;75(3):619-25; Life Sci. 2006 Jun 20;79(4):324-30; Cancer Lett. 2006 Jul 8;238(1):53-60.
416.38
Formula
C21H20O9
CAS No.
3681-99-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 86 mg/mL (206.5 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
Kakonein
other peoduct :
| In Vitro |
In vitro activity: Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. Pueraria is employed clinically to treat cardiovascular diseases in China. Another study showed that puerarin also possessed anti-cancer properties. Puerarin at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | In hypercholesterolmic diet plus administration of puerarin (300 mg/kg/day, p.o.) rats, Puerarin markedly attenuated the increased total cholesterol induced by hypercholesterolmic diet in both serum and liver. LD50: Mice 738mg/kg (i.v.) |
| Animal model | |
| Formulation & Dosage | |
| References | Pharmacol Biochem Behav. 2003 Jun;75(3):619-25; Life Sci. 2006 Jun 20;79(4):324-30; Cancer Lett. 2006 Jul 8;238(1):53-60. |
