product name Proparacaine HCl
Description: Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM. Proparacaine is more potent and less toxic than cocaine. Proparacaine significantly increases in FHV-1, C. felis, and 28S rDNA Ct values when fusidic acid is used. Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception.
References: Exp Eye Res. 1994 Apr;58(4):469-78; Neurosci Lett. 2009 May 1;454(3):249-53.
330.85
Formula
C16H26N2O3.HCl
CAS No.
5875-06-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 12 mg/mL (36.3 mM)
Water: 66 mg/mL (199.5 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Saline: 30 mg/mL
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Proparacaine is more potent and less toxic than cocaine. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade. |
| Animal model | Male Sprague–Dawley rats |
| Formulation & Dosage | Dissolved in saline; 10 μmol/kg; Intrathecally |
| References | Exp Eye Res. 1994 Apr;58(4):469-78; Neurosci Lett. 2009 May 1;454(3):249-53. |
