product name Progesterone
Description: Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone plays an important role in establishing uterine receptivity for embryo implantation. Cooperated with nuclear progesterone receptor, progesterone could damper the action(s) of E2 and BPA on Egr1 expression. When tested with mouse melanoma (B16F10) cells and human melanoma (BLM) cells, progesterone treatment could significantly inhibit mouse melanoma cell growth.
References: J Biol Chem. 1998;273(17):10696-701; Nature. 2010;465(7299):803-7; J Neurosci. 2007;27(48):13357-65.
314.46
Formula
C21H30O2
CAS No.
57-83-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 22 mg/mL (70 mM)
Water: <1 mg/mL
Ethanol: 63 mg/mL (200.3 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1941795
| In Vitro |
In vitro activity: Progesterone has biphasic effects on proliferation of breast cancer cells; it stimulates growth in the first cell cycle, then arrests cells at G1/S of the second cycle accompanied by up-regulation of the cyclin-dependent kinase inhibitor, p21. Progesterone-mediated transcription is further prevented by overexpression of E1A, suggesting that CBP/p300 is required. Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. Progesterone treatment increases the sensitivity of cortical synaptoneurosomes to GABA (i.e., decreased the EC50) and increases the maximal efficacy with which GABA stimulated Cl- transport (i.e., increased the Emax). Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Progesterone blocks the beneficial effect of estrogen on Abeta accumulation but not on behavioral performance in female 3xTg-AD mice. Progesterone significantly reduces tau hyperphosphorylation when administered both alone and in combination with estrogen. Progesterone-treated rats are less impaired on a Morris water maze spatial navigation task than rats treated with the oil vehicle. Progesterone-treated rats also show less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area. |
| Animal model | |
| Formulation & Dosage | |
| References | J Biol Chem. 1998 Apr 24;273(17):10696-701; Nature. 2010 Jun 10;465(7299):803-7; J Neurosci. 2007 Nov 28;27(48):13357-65. |
