product name Polydatin
Description: Polydatin (also known as Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc. It is also known as a PLA2 inhibitor which reduces Phospholipase A2 (PLA2) activity and sPLA2-IIA mRNA expression and mitigates LPS-induced lung injury by increasing increased Clara cell secretory protein (CCSP) expression.
References: BMC Cell Biol. 2011 Jul 25;12:31; Mediators Inflamm. 2013;2013:354087.
390.38
Formula
C20H22O8
CAS No.
65914-17-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 78 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
Piceid
other peoduct :
| In Vitro |
In vitro activity: Polydatin, known as a PLA2 inhibitor, reduces Phospholipase A2 (PLA2) activity and sPLA2-IIA mRNA expression and mitigates LPS-induced lung injury by increasing increased Clara cell secretory protein (CCSP) expression. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Pretreatment with Polydatin (15, 45, and 100 mg/kg) dose-dependently reduces sepsis-induced mortality and lung injury in cecal ligation and puncture (CLP-)induced sepsis mice through inhibiting CLP-induced serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production, lung cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) protein expressions and NF-kappaB activation. LD50: Mice 1g/kg (i.p.). |
| Animal model | |
| Formulation & Dosage | |
| References | BMC Cell Biol. 2011 Jul 25;12:31; Mediators Inflamm. 2013;2013:354087. |
