product name Piperine
Description: Piperine (also known as 1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide. Piperine has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. Piperine is found to be cytotoxic towards DLA and EAC cells and could inhibit the solid tumor development in mice induced with DLA cells.
References: J Pharmacol Exp Ther. 2002 Aug;302(2):645-50; J Ethnopharmacol. 2004 Feb;90(2-3):339-46.
285.34
Formula
C17H19NO3
CAS No.
94-62-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 57 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: 57 mg/mL (199.8 mM)
Solubility (In vivo)
Synonyms
1-Piperoylpiperidine
other peoduct :
| In Vitro |
In vitro activity: Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide. Piperine has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. Piperine is found to be cytotoxic towards DLA and EAC cells at a concentration of 250 μ g/ml. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Piperine (1.14 mg/dose/animal) could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor. LD50: Mice 15.1mg/kg (i.v.), 43mg/kg (i.p.), 200mg/kg (s.c.), 330mg/kg (i.g.); Rats 33.5mg/kg (i.p.), 514mg/kg (i.g.) |
| Animal model | |
| Formulation & Dosage | |
| References | J Pharmacol Exp Ther. 2002 Aug;302(2):645-50; J Ethnopharmacol. 2004 Feb;90(2-3):339-46; Toxicol Lett. 1983 May;16(3-4):351-9. |
