product name Pancuronium dibromide
Description: Pancuronium dibromide, also known as Pavulon and NA-97, is a competitive nicotinic acetylcholine receptor antagonist with IC50 of 5.5 nM, it is used as a muscle relaxant. As a neuromuscular blocking agent, Pancuronium bromide is more potent than curare but has less effect on the circulatory system and on histamine release. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate.
References: Eur J Pharmacol. 2001 Feb 9;413(1):31-5; Cancer Res. 1996 Jun 1;56(11):2556-60.
732.67
Formula
C35H60N2O4.2Br
CAS No.
15500-66-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (136.5 mM)
Water:100 mg/mL (136.5 mM)
Ethanol: 100 mg/mL (136.5 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19390254
| In Vitro |
In vitro activity: Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine, characterized by decrease of the time constant of current decay. Pancuronium also results in competitive block of embryonic-type nicotinic acetylcholine receptor channels. Pancuronium increases heart rate, vecuronium and rocuronium produces positive inotropic effects, and vecuronium shortens refractoriness in isolated rat atria. Pancuronium (0.5 mM) induces a complete fade of the tetanic contraction while leaving the twitch unaffected in the extensor digitorum longus muscle of the rat. Pancuronium decreases the amplitude and increases the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz in the extensor digitorum longus muscle of the rat. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in high dose dogs by 82%. Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in low dose dogs by 40% and 55%. Pancuronium limits cerebral hyperemia during prolonged seizures by attenuating increases in blood pressure as a result of elimination of skeletal muscle activity in newborn pigs. Pancuronium results in a significant difference with control is observed at gallamine concentrations ranging from 0.032-0.32 mM in tracheal smooth muscle strips from guinea-pigs. |
| Animal model | |
| Formulation & Dosage | |
| References | Eur J Pharmacol. 2001 Feb 9;413(1):31-5; Cancer Res. 1996 Jun 1;56(11):2556-60. |
Related Posts
product name Pancuronium dibromide
Description: Pancuronium dibromide, also known as Pavulon and NA-97, is a competitive nicotinic acetylcholine receptor antagonist with IC50 of 5.5 nM, it is used as a muscle relaxant. As a neuromuscular blocking agent, Pancuronium bromide is more potent than curare but has less effect on the circulatory system and on histamine release. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate.
References: Eur J Pharmacol. 2001 Feb 9;413(1):31-5; Cancer Res. 1996 Jun 1;56(11):2556-60.
732.67
Formula
C35H60N2O4.2Br
CAS No.
15500-66-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (136.5 mM)
Water:100 mg/mL (136.5 mM)
Ethanol: 100 mg/mL (136.5 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19390254
| In Vitro |
In vitro activity: Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine, characterized by decrease of the time constant of current decay. Pancuronium also results in competitive block of embryonic-type nicotinic acetylcholine receptor channels. Pancuronium increases heart rate, vecuronium and rocuronium produces positive inotropic effects, and vecuronium shortens refractoriness in isolated rat atria. Pancuronium (0.5 mM) induces a complete fade of the tetanic contraction while leaving the twitch unaffected in the extensor digitorum longus muscle of the rat. Pancuronium decreases the amplitude and increases the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz in the extensor digitorum longus muscle of the rat. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in high dose dogs by 82%. Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in low dose dogs by 40% and 55%. Pancuronium limits cerebral hyperemia during prolonged seizures by attenuating increases in blood pressure as a result of elimination of skeletal muscle activity in newborn pigs. Pancuronium results in a significant difference with control is observed at gallamine concentrations ranging from 0.032-0.32 mM in tracheal smooth muscle strips from guinea-pigs. |
| Animal model | |
| Formulation & Dosage | |
| References | Eur J Pharmacol. 2001 Feb 9;413(1):31-5; Cancer Res. 1996 Jun 1;56(11):2556-60. |