product name PD-1/PD-L1 inhibitor 2
References: WO/2015034820 A1
419.52
Formula
C25H29N3O3
CAS No.
1675203-84-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 83 mg/mL (197.8 mM)
Water: <1 mg/mL (slightly soluble or insoluble)
Ethanol: 83 mg/mL (197.8 mM)
Solubility (In vivo)
Chemical Name
N-(2-(((2-methoxy-6-((2-methyl-[1,1-biphenyl]-3-yl)methoxy)pyridin-3-yl)methyl)amino)ethyl)acetamide
other peoduct :
| In Vitro | Kinase Assay:
Cell Assay: The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM. |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Nat Rev Cancer. 2012 Mar 22;12(4):252-64; |
