product name Oxaprozin
Description: Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity.
References: Curr Med Res Opin. 2004 Aug;20(8):1275-7.
293.32
Formula
C18H15NO3
CAS No.
21256-18-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 59 mg/mL (201.1 mM)
Water: <1 mg/mL
Ethanol: 27 mg/mL (92.0 mM)
Solubility (In vivo)
Synonyms
WY-21743
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19408346
| In Vitro |
In vitro activity: Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Curr Med Res Opin. 2004 Aug;20(8):1275-7. |
