product name Osthole
Description: Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets.
References: Thromb Haemost. 1989 Nov 24;62(3):996-9; J Pharmacol Exp Ther. 2005 Sep;314(3):1290-9.
244.29
Formula
C15H16O3
CAS No.
484-12-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 49 mg/mL (200.58 mM)
Water: <1 mg/mL
Ethanol: 49 mg/mL (200.58 mM)
Solubility (In vivo)
Synonyms
Osthol
other peoduct :
| In Vitro |
In vitro activity: Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. Osthole mediates cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells and may be a promising agent for treating osteoporosis. Osthole also suppresses the secretion of hepatitis B virus in cell culture by increasing the glycosylation of HBsAg. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |
